Glomerulus Module

Renal Tubule Module

UCSF Missing Link


Renal Physiology Modules 

Glomerular Filtration Module

This module presents the various physiologic mechanisms that affect glomerular filtration in an interactive setting.

Renal Tubule Module

This module was created to bring together the main points of tubule physiology and pharmacology that will be taught. After completing this module, you should be able to describe the mechanisms of ion transport along the different parts of the tubule, as well as understand the actions of five classes of diuretics.

Learning Objectives


  • Understand the patterns of ion movement and permeability characterisitics of each part of the tubule.
  • Explain the mechanism for solute reabsorption and secretion in the nephron.
  • Discuss the development of solute gradients and counter-current exchange.
  • Explain physiologic effects of ADH and Aldosterone as well as the Renin-Angiotensin system on tubule physiology.


  • Describe the mechanisms of action of four classes of diuretics.
  • Know the physiologic effects, clinical applications, and side effects of each prototype drug.


  • Identify the major gross structures of the kidney.
  • Identify the three cell types of the glomerulus.
  • Identify the brush border in the proximal tubule.